Concentration-response data for antimalarial drugs profiled against parental and pfcrt-edited parasite lines. Results show complete or partial reversal of resistance and increased sensitivity of GB4 parasites harboring the PfCRT mutations F145I and G353V, relative to the control lines and the Dd2 parasite expressing wild-type 3D7 against the drugs (A) monodesethyl-amodiaquine (md-ADQ); (B) quinine (QN); (C) chloroquine (CQ); and (D) the CQ active metabolite monodesethyl-CQ (md-CQ). Comparisons are shown between pfcrt-edited parasites and their isogenic GB4 or Dd2 controls. Significance was determined using Mann-Whitney U tests with N, n = 4.2; *, P < .05.