Schematic representation of the trial. (A) The trial consisted of a 24-week treatment that included a 2-week intensive course, in which PC-rTMS or sham-rTMS was applied daily (five times per week, Monday to Friday), followed by a maintenance phase in which the same stimulation was applied weekly for 22 weeks. (B) Location of the TMS coil on the scalp using neuronavigation, as visualized on a template head (top left), as well as the specific location in MRI space (bottom). Biophysical modelling based on simulated induced electric field are also shown for a representative subject (top right). (C) Cortical activity was evaluated with concurrent TMS and EEG applied over the PC and analysed in the temporal and oscillatory domain.