Per-patient diagnostic performance of segmental vs. territory flow metrics for CAD ≥50% categorization. (A) The AUC = 0.766 (0.706–0.825) of segmental stress flow was significantly greater than the territory stress flow AUC = 0.745 (0.683–0.807) and the global stress flow AUC = 0.712 (0.647–0.776, n = 245, P < 0.05 segmental vs. territory, P < 0.001 segmental vs. global, P < 0.001 territory vs. global). (B) The AUC = 0.709 (0.642–0.777) of segmental MFR was also significantly greater than the territory MFR AUC = 0.686 (0.617–0.756) and the global MFR AUC = 0.633 (0.561–0.705, n = 245, P < 0.05 segmental vs. territory, P < 0.0001 segmental vs. global, P < 0.0001 territory vs. global). (C) The AUC = 0.729 (0.663–0.796) of segmental RFR was not significantly different than the territory RFR AUC = 0.695 (0.626–0.764). AUC, area under the curve; CAD, coronary artery disease; MFR, myocardial flow reserve; RFR, relative flow reserve.