Clinical vs. patient-oriented outcomes. Traditionally, the medical world has viewed patient outcomes for cardiovascular trials as binary: death, myocardial infarction, stroke, revascularization yes/no—and such persuasive data drive guideline uptake and acceptance into clinical practice. As the paradigm shifts towards patient-centric care and patient-oriented outcomes, more weight should be placed on patient-related and -driven goals and outcomes, as these may drive socio-economic concerns such as impact on Gross Domestic Product of early retirement for adversely affected individuals. Reimbursement occupies the hinterland between interventions and outcomes (current focus) and qualitative metrics (future state).