Figure 2
![Endothelial-specific Poldip2 knock-out abrogates inflammatory gene expression in LPS-induced lung injury. LPS injection induced a significant increase in expression of inflammatory markers [Tnfα (A), Iκbα (B)), chemoattractant molecules [Cxcl1 (C), Cxcl2 (D)], and the vascular activation marker [Vcam1 (E)] in Poldip2 EC+/+ mice. This effect was significantly blunted in Poldip2 EC−/− mice. Graphs represent averages ± SEM (n = 5). P < 0.0001, $$$P < 0.001, $$P < 0.01, compared to PBS injected Poldip2 EC+/+ mice, ##P < 0.01, #P < 0.05, compared to LPS injected Poldip2 EC+/+ mice (two-way ANOVA, with Tukey’s correction).](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/cardiovascres/118/11/10.1093_cvr_cvab295/2/cvab295f2.jpeg?Expires=1749783918&Signature=0L1-PFeD6DY5r7XVYlqQW7x1GrAI9OE2vffGLQvh0i4CUCwQVvheJxbpZkxgTtvKL8Y-Jaqmn6ILjR8PsITS1eEgAKE3SqgRICgzMoFoIRvLkxIJNhz49uAxfj2JK8qZD-mA0dIhCe-GwMQORHgqjLjGEg73djnf4w5Qd7eRcIKq-N~85hySxGgd0YtQJcPDX03XfwgUpKNkw0lfFhV3BckTRacHOfRp2ixAJ7-dIvZAmcXLYVedQOssCgkp8C~YXlcsk9P-e-KFMpSPhVpD3-5G4gbWOlAhtcvTV-Ymyp5hlIq62xFiSFtTU5tgebAFKWzdM4alNW34N1dPhihO4w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Endothelial-specific Poldip2 knock-out abrogates inflammatory gene expression in LPS-induced lung injury. LPS injection induced a significant increase in expression of inflammatory markers [Tnfα (A), Iκbα (B)), chemoattractant molecules [Cxcl1 (C), Cxcl2 (D)], and the vascular activation marker [Vcam1 (E)] in Poldip2 EC+/+ mice. This effect was significantly blunted in Poldip2 EC−/− mice. Graphs represent averages ± SEM (n = 5). P < 0.0001, $$$P < 0.001, $$P < 0.01, compared to PBS injected Poldip2 EC+/+ mice, ##P < 0.01, #P < 0.05, compared to LPS injected Poldip2 EC+/+ mice (two-way ANOVA, with Tukey’s correction).
