Outcomes in the pivotal Left Atrial Appendage System Embolic Protection in Patients with Atrial Fibrillation (PROTECT AF) trial.53 CV, cardiovascular; ITT, intention-to-treat (Reproduced from Piccini JP, Sievert H, Patel MR: Left atrial appaendage occlusion: rationale, evidence, devices and patient selection. Eur. Heart J, 2017;38: 869–876., with permission).