Trajectories of soluble LOX-1 and associated coronary plaque volume changes in patients on statin therapy. (A) Line plot showing paired soluble LOX-1 plasma levels at baseline and 1-year follow-up in all patients. (B) Mean change in soluble LOX-1 plasma levels over 1 year in patients with coronary plaque volume regression. (C) Plasma soluble LOX-1 levels at both baseline and 1-year follow-up in subjects with plaque volume progression in non-infarct-related arteries. (D) Receiver operating characteristic curve (fitted) and corresponding area under the curve for the correct classification of plaque progression/regression in non-infarct-related arteries according to absolute changes in sLOX-1 (ΔsLOX-1). Note that grey lines indicate the corresponding 95% confidence interval. AUC, area under the curve; CI, confidence interval; non-IRA, non-infarct-related arteries; ROC, receiver operating characteristic curve; sLOX-1, soluble lectin-like oxidized low-density lipoprotein receptor-1.