Dosing chronology plots of four patients. Calendar date (mm/dd/yy) is shown on the horizontal axis, and 24-h clock time is shown on the vertical axis. Each blue dot indicates the electronically recorded time and date of dosing. The vertical tan lines depict missed doses, the width of which reflects the number of days without dosing. During the depicted periods of study, each patient took 90–91% of prescribed doses, with the indicated wide variations in the temporal patterns of dose omissions. Data from the iAdherence database (From Blaschke et al.  ²¹).