Kaplan–Meier analysis of lethal arrhythmic event-free survival during follow-up in Brugada syndrome cohort-I. (A) Lethal arrhythmic event-free survival during the follow-up period in Brugada syndrome probands carrying SCN5A rare variations (all SCN5A; n = 60) and SCN5A(−) (n = 355). Confidence bands indicate 95% pointwise CI. (B) Time course of Brugada syndrome patients with loss-of-function SCN5A mutations (n = 45) and non-loss of function (n = 15). Non-loss-of-function probands have no lethal arrhythmic events during the follow-up period. (C) Lethal arrhythmic event-free survival of loss of function (n = 45) vs. non-loss of function plus SCN5A(−) (n = 370). The dissociation between two survival curves is more pronounced than that in panel A.