Figure 2
Three-level sudden death risk stratification for the 49 liable anticancer drugs associated with isolated drug-induced long QT (low risk), ventricular arrhythmias without sudden death (moderate risk), and ventricular arrhythmias with sudden death (high risk) identified in VigiBase (through 1 January 2019). Absolute number of ventricular arrhythmias (N  VA) including torsade de pointes (associated (N  LQT + N  VA) or not with diLQT reports by drug and sudden death risk level is displayed in (A) and (B), respectively. The corresponding proportion of such cases (N  VA or N  LQT + N  VA) over the total number of overall adverse drug reactions per drug (N  drug) are displayed in (C) and (D), respectively.

Three-level sudden death risk stratification for the 49 liable anticancer drugs associated with isolated drug-induced long QT (low risk), ventricular arrhythmias without sudden death (moderate risk), and ventricular arrhythmias with sudden death (high risk) identified in VigiBase (through 1 January 2019). Absolute number of ventricular arrhythmias (N  VA) including torsade de pointes (associated (N  LQT + N  VA) or not with diLQT reports by drug and sudden death risk level is displayed in (A) and (B), respectively. The corresponding proportion of such cases (N  VA or N  LQT + N  VA) over the total number of overall adverse drug reactions per drug (N  drug) are displayed in (C) and (D), respectively.

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