Study scheme and hypothesis: TRPC6 inhibition provides a complementary strategy for inhibition of neointima formation by blocking migration and proliferation of smooth muscle cells. DAG, diacylglycerol; ER, endoplasmic reticulum; IP₃(-R), inositol trisphosphate (receptor); LC, liquid chromatography; MS, mass spectrometry; PDGF, platelet-derived growth factor; mTOR, mammalian target of rapamycin; PIP₂, phosphatidylinositol-4, 5-bisphosphate; PI3K, phosphoinositide 3-kinase; PLC, phospholipase C.