In a single scan, multisystem 18F-FDG-PET imaging allows simultaneous interrogation of vascular inflammation, psychological stress, and bone marrow activation following myocardial infarction. Moderate associations are observed between 18F-FDG activity in these disparate organ systems; however, further work is now required to assess the causality and directionality or these associations. Several potential pathways that might exist in isolation or in combination to explain these associations are outlined