H19 therapy is effective in hypertrophic hearts. (A) Schematic representation of the experimental design with murine and human H19 (AAV9-H19, AAV9-hH19 compared to empty vector AAV9-empty). (B) Heart-weight-to-Tibia-length ratios (HW/TL) of Sham- or TAC-operated mice and (c) cardiomyocyte size (n = 6; DAPI = 4′,6-diamidino-2-phenylindole; TAC, transverse aortic constriction; WGA, wheat germ agglutinin coupled to Alexa Flour 488). (D) Echocardiographic analysis. (E) Tesc expression levels. (F) Expression levels of Nfatc3, Nppb, and Mcip1.4. Data are means ± SD. P-values were determined by one-way ANOVA with Bonferroni correction.