Figure 2
H19 knock-out exacerbates cardiac hypertrophy in vivo. (A) Schematic representation of the experimental design. (B) Heart weight-to-tibia-length ratio (HW/TL) of H19 KO and wild-type littermates (Wt) and (C) cardiomyocyte size (n = 6; DAPI = 4′,6-diamidino-2-phenylindole; TAC, transverse aortic constriction; WGA, wheat germ agglutinin coupled to Alexa Flour 488). (D) Expression of hypertrophic marker genes Nppb (natriuretic peptide B) and Mcip1.4 (myocyte-enriched calcineurin-interacting protein 1.4). (E) Microarray analysis of fractionated cardiomyocytes from H19 KO and Wt animals (n = 3) 6 weeks after TAC represented as heatmaps of indicated gene sets. Data are means ± SD. P-values were determined by one-way ANOVA with Bonferroni correction.

H19 knock-out exacerbates cardiac hypertrophy in vivo. (A) Schematic representation of the experimental design. (B) Heart weight-to-tibia-length ratio (HW/TL) of H19 KO and wild-type littermates (Wt) and (C) cardiomyocyte size (n = 6; DAPI = 4′,6-diamidino-2-phenylindole; TAC, transverse aortic constriction; WGA, wheat germ agglutinin coupled to Alexa Flour 488). (D) Expression of hypertrophic marker genes Nppb (natriuretic peptide B) and Mcip1.4 (myocyte-enriched calcineurin-interacting protein 1.4). (E) Microarray analysis of fractionated cardiomyocytes from H19 KO and Wt animals (n = 3) 6 weeks after TAC represented as heatmaps of indicated gene sets. Data are means ± SD. P-values were determined by one-way ANOVA with Bonferroni correction.

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