Comparison of the treatment effect of active vs. placebo procedures for binary primary outcomes. ^aComposite of death, myocardial infarction, repeat target lesion or percutaneous revascularization, and coronary artery bypass graft. ^bResponder rate was defined as a blood pressure drop ≥10 mmHg in systolic office blood pressure as a part of a composite outcome. ^cResponse was defined as an increase in office systolic blood pressure >35 mmHg while the baroreflex activation therapy device was turned off. BP, blood pressure; CCS, Canadian Cardiovascular Society; MACE, major adverse cardiovascular events; PFO, patent foramen oval.