Figure 10
Cntnap2  −/− neurons have delayed currents and fire more easily but elicit fewer maximum spikes. (A) Sample current clamp recordings of wildtype (grey) and Cntnap2−/− (black) neurons with labeled metrics of interest. Action potential features presented are (B) action potential peak voltage, (C) action potential half-width, (D) fast trough of after-hyperpolarization, (E) after-hyperpolarization slow trough, and (F) first interspike interval. (G) Firing frequency in response to increasing steady-state current injections as indicated. All data are represented as mean ± SE (B, G: wildtype n = 16 cells; C, F: wildtype n = 15 cells; D: wildtype n = 17 cells; E: wildtype n = 14 cells; B–G: Cntnap2−/−n = 10 cells). *P <0.05.

Cntnap2  −/− neurons have delayed currents and fire more easily but elicit fewer maximum spikes. (A) Sample current clamp recordings of wildtype (grey) and Cntnap2−/− (black) neurons with labeled metrics of interest. Action potential features presented are (B) action potential peak voltage, (C) action potential half-width, (D) fast trough of after-hyperpolarization, (E) after-hyperpolarization slow trough, and (F) first interspike interval. (G) Firing frequency in response to increasing steady-state current injections as indicated. All data are represented as mean ± SE (B, G: wildtype n = 16 cells; C, F: wildtype n = 15 cells; D: wildtype n = 17 cells; E: wildtype n = 14 cells; BG: Cntnap2−/−n = 10 cells). *P <0.05.

Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close