Cntnap2  ^−/− rats have a reduced ability to consistently respond to a six-pulse noise burst train. (Left) responses of multiunit clusters in the primary auditory cortex to a six-pulse train of 25 ms noise burst stimuli (90 dB SPL), presented at repetition rates of 0.3, 0.9, 2.8, 5.2, 7.4, and 9.2 pps, represented as an averaged line PSTH from wildtype (n = 176 clusters) and Cntnap2^−/− (n = 161 clusters) rats. Solid line and shaded region denote mean ± SE. Horizontal dashed line represents spontaneous activity. (Right) average firing rate in a 35 ms window (5–40 ms after stimulus onset) in response to each noise burst in the six-pulse train for each repetition rate, represented as mean ± SE. Horizontal dashed line represents spontaneous activity. As the repetition rate increases, the ability of multiunit clusters to respond to each noise burst stimulus in the six-pulse train decreases; this effect is more pronounced in the responses of Cntnap2^−/− rats at rates of 5.2 pps and greater. ^*P <0.05.