Spiking profiles in Cntnap2^−/− rat auditory cortex is hyper-responsive. (A) Multiunit cortical response dynamics in the primary auditory cortex to a 50 ms noise burst stimulus (90 dB SPL), represented as an averaged line PSTH from wildtype (n = 180 clusters) and Cntnap2^−/− (n = 161 clusters) rats. Solid line and shaded region denote mean ± SE. Horizontal dashed line represents spontaneous activity. (B) Spontaneous activity, (C) response onset latency, (D) response duration, (E) average response firing rate, (F) peak firing rate, (G) peak latency, (H) the rebound response firing rate, and (I) the onset of the rebound response represented as mean ± SE. Longer response duration and increased firing rate are indicative of a hyperexcitable response. ^*P <0.05.