Urinary glucocorticoid metabolites defining ACRD/CRD. (A) Children. All diagnosed CRD/ACRD children (n=5; ACRD: closed circle, 6 years; closed triangle, 7 years; closed square, 4 years; CRD: open circle, 8 years; open triangle, 13 years) plotted on a log scale for a range of glucocorticoid metabolites found in urine, plotted against an age-matched reference cohort (grey box plots: age 1–7 years, n=22, 12 boys and ten girls; white box blots: age 8–14 years, n=31, 13 boys and 18 girls). (B) Adult females. All diagnosed CRD/ACRD adult females (n=5; closed symbols represent ACRD and white circles represent CRD cases) plotted on a log scale for a range of glucocorticoid metabolites found in urine, plotted against an age-matched reference cohort (age 18–63 years; n=89). Box plots represent the interquartile ranges (25th–75th percentiles), and whiskers represent the 5th and 95th percentiles. For steroid abbreviation, please refer to Patients and methods section.