Figure 2
Abnormal RV systolic and diastolic stress response in obesity. Study participants (n = 27) with class I–II obesity or healthy weight underwent cine CMR before and during dobutamine stress; a subgroup also underwent 31P MRS for energetics. Participants with obesity had a delayed peak of diastolic RV filling at rest consistent with diastolic dysfunction, an attenuated stress inducible increase in RV ejection fraction, and an impaired stress inducible change in peak RV filling rate (a measure of stress RV diastolic dysfunction). There was a non-significant numerical trend to greater cardiac energetic deficit during stress in obesity. Data are presented as mean ± standard deviation, *P < 0.05, **P < 0.01, ***P < 0.001.

Abnormal RV systolic and diastolic stress response in obesity. Study participants (n = 27) with class I–II obesity or healthy weight underwent cine CMR before and during dobutamine stress; a subgroup also underwent 31P MRS for energetics. Participants with obesity had a delayed peak of diastolic RV filling at rest consistent with diastolic dysfunction, an attenuated stress inducible increase in RV ejection fraction, and an impaired stress inducible change in peak RV filling rate (a measure of stress RV diastolic dysfunction). There was a non-significant numerical trend to greater cardiac energetic deficit during stress in obesity. Data are presented as mean ± standard deviation, *P < 0.05, **P < 0.01, ***P < 0.001.

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