Comparison of integration enrichment across various genomic features in HepG2 cells. We compared the enrichment at features that are associated with MLV integration to measure their ability to explain non-random integration. We calculated enrichment as described in the caption of Figure 3. The error bars represent the standard deviation of the enrichment ratio, and the dotted line indicates the level of enrichment expected by chance. The enrichment values for each feature are all significantly different from random (determined as above, by bootstrapping; significance threshold = 0.00625; all differences from random have P < 0.0001), and different from each other, as determined by analysis of variance (P < 2 × 10−16) and Tukey’s multiple comparisons of means (all pairs differ with adjusted P < 10−7). Labels: state 4, the state 4 strong enhancers; DNAse, DNAse-sensitive regions; TSS, regions within 5 kb of a transcription start site; sequence, sites matching the TNVNNBNA motif.
