Enrichment of integrations in ChIP-seq peaks of chromatin marks in HepG2 cells. We compared experimental integrations and integrations in the 10 000 matched random control data sets to ChIP-seq peaks from the ENCODE project (29). We calculated enrichment as described in the caption of Figure 3. The error bars represent the standard deviation of the enrichment ratio. The dotted line indicates the level of enrichment expected by chance. The experimental integration counts for all marks are significantly different from random (determined as above, by bootstrapping; significance threshold = 0.0028; all differences from random have P < 0.0001). The enrichment values for each mark are all significantly different from each other, as determined by analysis of variance (P < 2 × 10−16) and Tukey’s multiple comparisons of means (all pairs differ with adjusted P < 10−7).
