Staining patterns obtained by superimposing transactivation-responsive DNA-binding protein 43 pathology on 1C2-positive neurons in 3 patients with Spinocerebellar ataxia type 2. Cytopathological patterns of 1C2 and TDP-43 labeling were classified as follows: pattern A, cytoplasmic 1C2 and nuclear TDP-43; pattern B, nucleocytoplasmic 1C2 and nuclear TDP-43; pattern C, nuclear 1C2 and cytoplasmic TDP-43. The frequencies of patterns A and B were similar between patients. The frequency of pattern C was lowest in Patient 1, intermediate in Patient 2, and highest in Patient 3.