A case of a 55-year-old man with cardiac amyloidosis (TTR-wt). A severe left ventricular hypertrophy, a severe diastolic dysfunction, and a moderate left ventricular systolic dysfunction were present and were associated with low QRS voltages in limb leads. The patient underwent cardiac transplantation 6 months after this clinical evaluation because of several hospitalizations for heart failure and worsening of systolic function.