Transcriptomics changes in the liver of 1,4-DX-exposed mice. A, Principal components analysis scores plot of transcriptomics data from liver samples of mice exposed to 0 (light gray circles) or 5000 mg/L (black circles)1,4-DX in water (vehicle) for 4 weeks. B, Hierarchical clustering analysis heatmap showing the 65 differentially expressed (FDR-corrected p-value > .05 and log₂ fold-change >1.5) genes in livers of mice exposed to 0 (light gray squares) and or 5000 mg/L (black squares) 1,4-DX for 4 weeks. The log₂ fold-change in expression in 1,4-DX-exposed mice are shown on a scale from −2.0 (blue) to 2.0 (gold).