Performance of a multiple PRE score in predicting the effect of various drugs on kidney outcomes using the short-term change in multiple biomarkers. The performance of the score was assessed in completed clinical trials with known outcomes (retrospective validation), and using data from phase 2 studies to predict the outcomes of ongoing phase 3 studies (prospective validation). The score was applied to trials with ARB, losartan (RENAAL trial) and irbesartan [IDNT (Irbesartan Diabetic Nephropathy Trial) trial]; the Glucagon like Petide-1 Receptor Agonists exenetide [EXSCEL (Exenatide Study of Cardiovascular Event Lowering) trial]; the endothelin receptor antagonist atrasentan (prediction of the SONAR trial) and the SGLT2i dapagliflozin [prediction of the DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial]. The predicted effect of the drug is shown in blue bars and the observed effect in grey bars.