CLE clades contain both tick endosymbionts and pathogens. A 16S rDNA-based phylogenetic tree is shown. Bootstrap support and posterior probabilities are labeled above and below branchpoints, respectively. Nodes with ≤70% bootstrap support were collapsed to polytomies. Taxa colors represent the continent from which the host was derived. Established pathogens are marked with asterisks. Clades A–D were originally defined by Duron et al. (2015a).