Group (a,c,e; mean and standard error of mean) and typical profiles within each group (b,d,f) of cortisol in serum (total) and in subcutaneous and intravenous compartments (free fraction). Saline (a,b), 250 µg Synacthen (c,d), or 1mg dexamethasone (e,f) were administered by 11:02 hours. Sampling commenced at 10:00 for serum, and at 09:55 for SC & IV with ten minutely samples being collected up to 15:00. Lunch was served at 12:00.