Direct translation of differential gene expression and pathway enrichment yield few results between 22q11DS mouse preclinical model and human cohort. (A) Volcano plots of DEGs within the one-to-one human-mouse ortholog subsets of the Ms22q11DS and HuSZ cohorts, FDR < 0.05. (B) Venn diagram representation of distinct DEGs (FDR < 0.05) within the Ms22q11DS and HuSZ cohorts and shared downregulation of 3 genes between the two cohorts. (C) Significantly enriched pathways associated with the 22q11DS phenotype within the mouse cohort, FDR < 0.05.