Contribution of CYP450 isoforms to the metabolism of ADB-BUTINACA. (A) The effect of CYP450-specific chemical inhibitors on the remaining amount of ADB-BUTINACA after 30 min incubation in human liver microsomes. Data are shown as mean ± SD. Results were compared between control and each inhibitor (*P = 0.0276; **P < 0.0001). (B) Remaining amount of ADB-BUTINACA for each recombinant CYP450 isoform vs incubation time. Data are shown as mean ± SD. Line represents linear regression curve. (C) Relative contribution of each CYP450 isoform to the overall metabolism of ADB-BUTINCA calculated via Eq. 2.