Cell types and cell-type-specific gene signatures identified in the human hepatocellular cancer (HCC) tumors and paired normal tissues based on single-cell RNA sequencing. (A), Schematic diagram of workflow for single-cell RNA sequencing. (B), Visualization of cell types for 17 176 HCC and adjacent nontumor liver cells using t-distributed stochastic neighbor embedding (t-SNE). (C), Expression patterns of those representative cell-type-specific gene signatures. (D), Heatmap plot for the expression of the cell-type-specific gene signatures.