Overexpression of peptidyl prolyl isomerase A (PPiA) promotes Mycobacterium tuberculosis (Mtb) survival in the murine model of infection. A, Gross morphology of lung and spleen of mice infected with indicated strains at 8 weeks postinfection. Arrowheads represent granulomatous lesions. B, Eight weeks postinfection lung tissues from infected animals were harvested, fixed, and stained with hematoxylin and eosin for histopathological analysis. Photomicrograph depicts the granulomatous lesion. C and D, Bacterial loads in the lungs and spleen of Balb/c mice infected with indicated strains. *P<.05; **P<.005. Abbreviations: AS, alveolar space; CFU, colony-forming units; E, epithelioid cells; G, granuloma; L, lymphocytes.