Significant CSF peptidomic response to pulmonary MWCNT exposure. CSF collected 4 h after MWCNT exposure was fractionated to enrich for endogenous peptides and analyzed by ion mobility-enabled data-independent mass spectrometry. A, Heat map representation of CSF peptide responses to 10 or 40 µg MWCNT exposures relative to the 0 µg control group. The log2 relative ion intensity is colored per the shown scale. B, The log(2) ion intensity relative to the 0 µg control group for identified peptides across 10 and 40 µg MWCNT exposures. Data are presented as mean ± SEM, n = 6–7/group. *p < .05; **p < .001.