ROIs analysis of the regional ADC values in different brain areas among the mild (N = 7), moderate (N = 8) and severe (N = 8) damage outcome groups at each time point after HI. The mean ADC values in the ipsilateral cortex in A, thalamus in B, hippocampus in C, striatum in D and corpus callosum in E within 6 h, at 24 h and 7 days after HI. The error bars were standard deviation. Significance level (*P < 0.05 and **P < 0.005) among groups at each time point was determined by using an unpaired 2-way ANOVA with post hoc tests (the cortex F_4,66 = 29.592, P < 0.001; the thalamus F_4,66 = 2.881, P = 0.03; the hippocampus F_4,66 = 6.673, P < 0.001; the striatum F_4,66 = 1.926, P = 0.118 and the corpus callosum F_4,66 = 10.590, P < 0.001).