EPT test. (A) Per cent of time spent exploring the open arms over the total time of exploration. (B) Per cent of entries in the open arms over the total number of entries. (C) Number of head dipping during the 5 min of testing. (D) Number of rearings during the 5 min of testing. (E) Number of stretched-attend postures during the 5 min of testing. Statistical significance has been calculated with the Unpaired t-test with the Welch’s correction. In all panels, open circles represent WT (n = 23 rats) and solid circles represent SESN3-KO rats (n = 37 rats). Statistical analysis in A and B: Mann–Whitney U-test. Statistical analysis in B and C: unpaired t-test with Welch’s correction. **P < 0.01; ***P < 0.001.