CGF extract modulated macrophage cytokine secretion. (A) The supernatants of CCM-treated macrophages were screened using a human cytokine antibody array. (B) Representative cytokines are presented. (C) A GO analysis of differentially expressed cytokines enriched in BP terms after 20% CCM treatment. (D) Enriched MF categories. (E) The mRNA expression of differentially expressed cytokines (IL-1β, IL-7, RANTES and MCP-1) in CCM-treated macrophages was analyzed using q-PCR. (F) The secretion of IL-1β and RANTES by CCM-treated macrophages was further confirmed using ELISAs. The quantitative data are presented as the mean ± SD (n = 3) and were analyzed using one-way analysis of variance (ANOVA) and post hoc Dunnett tests: *P < 0.05, **P < 0.01 and ***P < 0.001.