Permutation results, severe patients. The areas shown are those for which connectivity was specifically important for the distinction between fitters and non-fitters in the severely impaired patient group, as revealed by the permutation analyses for 2 weeks (top) as well as white matter change up to 3 months (bottom). The colour indicates how many connections for each area showed specificity. Areas with at least two specific connections are shown; all areas are plotted on the inflated FreeSurfer brain as well as the MNI standard brain with z-coordinates given. See Supplementary Table 7 for the full results. AH = affected hemisphere.