System segregation moderates the association between Alzheimer’s disease severity and cognition. Interaction effect of system segregation by disease progression markers on cognitive performance in autosomal dominant (A and B) and sporadic Alzheimer’s disease (C and D). Note that interaction effects were determined using continuous values of system segregation, while median splits are for illustrational purposes only. Note that higher scores on the ADAS13 (C) indicates worse cognition, whereas higher scores on the composite measures (A, B and D) indicate better cognition.