Association of systemic inflammatory regulators with Alzheimer’s disease using Mendelian randomization (validation proteome GWAS, with SNPs reaching p < 5 × 10^–6). More than one set of data were available for some exposures. Their corresponding IDs were provided. Odds ratio (OR) and 95% confidence interval (CI) represent the change in the odds ratio of Alzheimer’s disease per 1-SD increase in the systemic inflammatory regulator level. * indicates results after removing SNPs associated with age at recruitment. After correcting for multiple comparison, p-value < 0.05/29 = 0.0017 was considered as significant. CCL3, macrophage inflammatory protein-1α; CCL5, regulated on Activation, Normal T Cell Expressed and Secreted; CCL7, monocyte-specific chemokine 3; CCL11, Eotaxin-1; CCL27, cutaneous T-cell attracting chemokine; CELC11A, stem cell growth factor beta; CSF1, macrophage colony-stimulating factor 1; CSF3, granulocyte colony-stimulating factor; CXCL1, growth-regulated oncogene-α; CXCL9, monokine induced by interferon gamma; CXCL10, r interferon-gamma-induced protein 10; HGF, hepatocyte growth factor; IFNg, interferon gamma; IL, interleukin; KITLG, KIT ligand; LTA, lymphotoxin-alpha; MIF, macrophage-migration inhibitory factor; PDGFB, platelet-derived growth factor subunit B; SNPs, single-nucleotide polymorphisms; TNF, tumour necrosis factor.