Voxel-based interaction analyses revealed that APOE-by-sex interactive effect was associated with tau load in medial temporal regions.APOE-by-sex interactive effect was significantly associated with tau load in medial temporal regions. Images represent voxel-based t-statistical parametric maps (corrected for multiple comparisons; cluster threshold of P < 0.001) overlaid on the structural MRI ADNI reference template. Age, educational attainment and clinical diagnosis were used as covariates in the models. Analyses performed with and without correction for amyloid were presented in B and A, respectively.