Correlation of GCN modules with age and their change in connectivity between old and young queens. A positive correlation with age (y axis) signifies an upregulation of a module in old queens. A positive log2-fold change in connectivity (x axis) represents a higher connectivity in old queens. Modules are labeled with their assigned module numbers. Sizes of dots represent relative number of genes within modules. Modules with red outlines are significantly upregulated and modules with blue outlines are significantly downregulated in old queens compared with young queens.