Sub-group comparison (Intact minus Impaired) within LTLE. (A) Whole brain surface rendering and slices revealing significant activation (SME minus Math contrast) resulting from t-test of sub-group difference (intact minus impaired) within the LTLE patients (P_FDRt-statistic corrected, <0.05, cluster level). Results highlight the areas where the SME/Math difference is significantly larger in the LTLE patients with intact compared to impaired performance levels on the PAM task. (B) FC results of gPPI using bilateral hippocampal region emerging from the t-test effect (see A) as seed. Seed clusters of left (MNI coordinates of maxima: −20 –24 −18; 75 voxels) and right (14 –22 14; 72 voxels) hippocampus, involving the time course of the SME minus Math contrast was extracted and the generated gPPI regressor effects (gPPI_β) are displayed. Results revealed 10 target regions with functional relationship of statistically significant strength with combined hippocampal seed (P_FDRt-statistic corrected < 0.05). (C) Bar diagram presented effect size (mean beta weights from gPPI) for each functional relationship between the source seed (combined left and right hippocampus) and target regions.