Expression patterns of ICGs. (A) The t-SNE result of classifying solid tumor cells, activated immune cells and inhibited immune cells using the expression of 68 ICGs (from FANTOM5 project). (B) Three expression patterns of ICGs in immune cells and tumor cells: TC-ICGs, IC-ICGs, immune cells dominate; TIC-ICGs, tumor and immune cells bivariate. These were classified by comparing the UQ expression of each ICG between immune and tumor cells. (C) The expression levels of six ICGs shows three expression patterns in tumor and immune cells. (D) Independent validations of ICG expression patterns using two single-cell datasets.