Identification and characterization of molecular subtypes in patients with hepatocellular carcinoma. (A) Identification of survival-related regulation modules among clinical targetable genes. (B) Subgroups are identified based on gene expression data of LIHC cohort by k-means consensus clustering upon their abundance. k was examined from 2 to 6 and consensus clustering was based on 100 resampled datasets. (C) Heatmap of difference score in two subgroups. (D) The hypoxia scores in different subgroups. (E) The mutation burden for patients in different subgroups. (F) The proportion of patients that response to chemotherapy in all available treatment information in two subgroups. (G) Kaplan–Meier curves for overall survival based on the two subgroups (Log-rank test).