Identification of PPS-related biological processes and drug targets. (A) An overview of the association between PPS and PDS. The correlation coefficient and significance are determined using Spearman’s correlation. (B) The result of gene set enrichment analysis shows high PPS score-associated (red) and low PPS score-associated (blue) biological processes (see also Table S9 available online at https://dbpia.nl.go.kr/bib). Color toward gray on the plot indicates no statistical significance. (C) Two representative GSEA enrichment plots of the ‘Myc targets v1’ and ‘Myc targets v2’ hallmarks. (D) Volcano plot (left) and scatter plots (right) of Spearman’s correlations and significance between PPS scores and protein expression of drug targets (see also Table S11 available online at https://dbpia.nl.go.kr/bib). Red dots indicate the significant positive correlations (P < 0.05, and Spearman’s r > 0.3). (E) Volcano plot (left) and scatter plots (right) of Spearman’s correlations and significance between PPS score and CERES score of drug targets (see also Table S11 available online at https://dbpia.nl.go.kr/bib). Blue dots indicate the significant negative correlations (P < 0.05, and Spearman’s r < −0.5). TP53-mutant hepatoma cell lines are labeled on the scatter plots.