Annotation and filtration page of PedMiner. (A) Detail annotation information of the variants displayed in the table. (B) Detail annotation information of the genes displayed in the table. (C) Default three-step filtration process. (D) Variant filtration item and threshold, users can filter variants based on the variant consequence, population frequency, noxiousness software percent, gene function annotation and linkage region. (E) Genes within the linkage region.