Performance of 40-GPS to predict OS in three test datasets. (A–C) Kaplan–Meier curves of OS for high-risk and low-risk patients determined by 40-GPS in tests 1, 2 and 3. (D–F) Multivariate Cox analyses of 40-GPS after adjusting for age, sex, and stage in tests 1, 2, and 3, respectively. Solid squares represent the HR of death, and the close-ended horizontal lines represent the 95% CIs. HR and 95% CIs were generated using multivariate Cox regression models.