Serum DHA associations with entorhinal and hippocampal brain volume from Cohort 1 (n = 53). (A, B) There was a significant interaction between APOE genotype and DHA on left entorhinal volume (t = −2.20, P = 0.03). In ε3ε3 carriers (n = 38), serum-free DHA was significantly associated with right entorhinal volume and explained 20% of volume variability (R2 = 0.20, P = 0.005). Serum free DHA explained 8% of the variability in the left entorhinal volume (R2 = 0.08, P = 100). (C, D) No interaction between serum free DHA levels and APOE genotype on hippocampal volume was found, and no main effects of serum free DHA on hippocampal volume were found, although there was a trend towards significance. Confidence intervals represented by dotted curve lines are shown in for associations in the ε3ε3 groups.
