Active zone protein is affected in human synucleinopathy. (A, B) Quantitative western blots revealed no significant alteration in the expression levels of LIPRIN-α3 in the prefrontal cortex (BA9), cingulate cortex (BA24) and parietal cortex (BA40), while LIPRIN-α4 (B) was found to be downregulated in prefrontal cortex of DLB patients *P = 0.0389; (n = 8–10). (C) Representative images from the western blotting membranes. All graphs are represented as mean ± SEM shown. Statistical analyses were performed using one-way ANOVA test followed by post hoc Dunnett’s multiple comparison test. Full uncropped blots are available in Supplementary material.