Relationship between the left ventricular volume and the mitral regurgitation at rest and during exercise. Exercise increases LV EDV and EROA in this cohort. Compared with the characteristics of the two large previous studies, the relationship between LV EDV and EROA during exercise in this study was similar to that of the COAPT study. COAPT, Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation; EROA, effective regurgitant orifice area; LVEDV, left ventricular end-diastolic volume; Mitra-FR, Multi-center Randomized Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation. P value for resting vs. exercise values (^aLVEDV and ^bEROA)